Sensitizing antigen-specific CD8+ T cells for accelerated suicide causes immune incompetence
نویسندگان
چکیده
منابع مشابه
Sensitizing antigen-specific CD8+ T cells for accelerated suicide causes immune incompetence.
Death receptor-mediated activation-induced apoptosis of antigen-specific T cells is a major mechanism of peripheral tolerance induction and immune homeostasis. Failure to undergo activation-induced cell death (AICD) is an important underlying cause of many autoimmune diseases. Thus, enhancing the T cell's own suicide mechanism may provide an efficient therapy for the treatment of autoimmune dis...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2003
ISSN: 0021-9738
DOI: 10.1172/jci200316344